Research Discloses Several Genes that have an Effect on the Bones

A new genetic research conducted by a multinational team of researchers has revealed that a huge percent of genes in our bodies will probably affect the bone strength, possibly about 2,000 out of the 21,000 genes.

Finding genes that cause osteoporosis is the first vital step in assisting to provide treatment for this severe condition.

From the hundred ‘knockout mice’, the first produced on one pipeline created by  Wellcome Trust Sanger Institute, UK- as a part of the universal attempt to  knockout each gene in genome one after the other, the researchers found nine genes that seem to strengthen or weaken the bone. 

The researchers utilized digital X-ray microradiography and micro-CT along with load bearing and statistics experiments to evaluate whether each of initial hundred genes had an impact on the bone.

Professor Peter Croucher from the Garvan Institute of Medical Research in Sydney said that they wanted to look at what the screening of the initial hundred knockout mice from the pipeline told them about the effect of the genes on the bone.

Their effort was fruitful in that they found nine genes that were not described earlier. Each of them seemed to be vital in regulating the skeleton. This indicates that approximately around 8-10 percent of all the genes could be engaged in one way or the other.

Prof Croucher said that they believed an orderly screening of the knockout mice through this approach would give them the data scale they needed to describe the functional and structural changes in genes, which decide the strength of the bones. Microradiography and CT scans are supposed to give them the structural data they needed. Fracturing of the bones later tells them if there is a rise or fall in the structure propensity to the fracture and that is the functional point at which it ends.

He also went to say that this helped them in describing four functional categorization of bone. The normal bone is flexible and strong, while abnormal bone may be strong and brittle, weak and flexible or weak and brittle.

The scientists are now attempting to comprehend the possible function of the nine genes they have just been identified. The results indicate that if few of them were blocked, it would lead to greater bone mass as well as stronger bones. They are in the process of making antibodies to these genes to test their results.

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